Replication Between Two Percona XtraDB Clusters, GTIDs and Schema Changes

I got this question on the “How to Avoid Pitfalls in Schema Upgrade with Percona XtraDB Cluster (PXC)” webinar and wanted to answer it in a separate post.
Will RSU have an effect on GTID consistency if replication PXC cluster to another cluster?
Answer for this: yes and no.
Galera assigns its own GTID for the operations, […]